However, its structure and biochemical function have remained elusive.
Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila and mice. PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Crystal structure and activity of the endoribonuclease domain of the piRNA pathway factor Maelstrom. Matsumoto, N., Sato, K., Nishimasu, H., Namba, Y., Miyakubi, K., Dohmae, N., Ishitani, R., Siomi, H., Siomi, M. Genetic map position - chr3L:22717333-22719334Ĭellular location - nuclear and cytoplasmic Keywords - spindle-class protein, A/P polarity, D/V polarity
Function - potential regulator of RNA processing or subcellular location
0 kommentar(er)
